During her PhD at the “Service de santé des Armées” (Pr. Daniel Parzy’s unit), Christelle studied the cytokines and transcriptomic responses according to the severity of malaria due to Plasmodium falciparum in hyperendemic area (DRC, Africa). She collaborated to the establishment and follow-up of a clinical trial with local medical staff (Monkole, DRC). She also contributed to the development of a high throughput screening method by coupling of proteins or peptides to magnetic beads. Christelle joined the lab in March 2014 thanks to an ANR LabEx IBEID post-doctoral fellowship. She is studying the development of trypanosomes during the early stages of the infection in the mammalian host by intravital imaging approaches in vivo and the implication of the flagellum in host-parasite interactions.
SHERLOCK4HAT African trypanosomes are transmitted by the bite of the tsetse fly and cause the debilitating, and often fatal, neglected tropical disease sleeping sickness, or Human African Trypanosomiasis (HAT). Trypanosoma brucei gambiense, the parasites […]
AdipoTryp Trypanosoma brucei is a unicellular and extracellular parasite transmitted by the tsetse fly (Glossina genus) and causing Human African Trypanosomiasis (HAT) in Sub-Saharan Africa. If untreated, this neglected tropical disease has a case […]
Trypanosoma brucei gambiense causes chronic Human African Trypanosomiasis. These extra-cellular protist parasites are transmitted by tsetse flies and proliferate in the host blood. We have recently demonstrated that the skin was a major yet […]