One post-doctoral position is available in the Human Developmental Genetics Unit, to study the role of the DEAH-box RNA helicase DHX37 in human sex-determination (SD). The unit aims to understand cell fate choice and organogenesis by studying the molecular mechanism of SD in mammals as paradigm. The mammalian gonad is unique in being bipotential and emerging evidence suggests that commitment of a common progenitor to either male (Sertoli cell) or female (granulosa cell) fate is the outcome of a molecular conflict between mutually antagonistic male and female regulatory networks that canalize development down one pathway, whilst actively repressing the other. Recently we have provided evidence that an RNA helicase, DHX37, which is required for eukaryotic ribosome biogenesis, is involved in human sex-determination. This represents a major shift in our view of the process of SD and reopens the debate on functional ribosome specialization. The project aims to clarify the precise role of DHX37 in mammalian sex-determination and address wider questions of ribosome specialization.
Candidates should have proven research skills in cell biology, protein biochemistry protein-RNA, protein-protein interactions. Experience in ribosome biology will be a plus. The appointment will be financed by an ANR for three years. The starting date will be decided in agreement with the selected candidate.
Applications including a cover letter with a brief statement of research experience, technical expertise and interests, a CV, a list of publications and contact details of two referees, should be sent to: Anu Bashamboo (firstname.lastname@example.org) or Ken McElreavey (email@example.com)