A funded post-doctoral position is available to study the role of immunometabolism and metabolic interventions to achieve HIV remission. The successful applicants will develop their research in the “Viral Reservoirs and Immune Control Lab” headed by Asier Sáez-Cirión at Institut Pasteur in Paris.
The laboratory is interested in developing new therapeutic strategies inspired by the mechanisms associated with control of HIV infection in rare individuals who are able to maintain undetectable viral loads for very long periods of time in the absence of antiretroviral treatment. The research program will be focused on recent results from the laboratory showing that cell metabolism is a critical determinant of HIV infection on CD4+ T cells and of the efficacy of HIV-specific CD8+ T cells. The program includes the analyses of cells from metabolic interventions in preclinical models. Experimental approaches will cover cellular biology, immunology and virology.
Requirements
The applicant must have a PhD with research skills in the fields of immunology/infectious diseases, be strongly motivated by the study of virus/host interactions, be a team player and have good skills in communicating in English (oral and writing). Experience in flow cytometry is an important asset for this program.
Position: The position is available immediately and will remain open until filled. The position is initially for 2 years, with the possibility of extension. Salary is commensurate with experience according to Institut Pasteur guidelines.
Applications including a curriculum vitae and a cover letter detailing your skills and motivations should be sent by email to: asier.saez-cirion(at)pasteur.fr
Perdomo-Celis F, et al. Reprogramming dysfunctional CD8+ T cells to promote properties associated with natural HIV control. J Clin Invest. 2022 Jun 1;132(11):e157549. doi: 10.1172/JCI157549. PMID: 35380989;
Sáez-Cirión A, Sereti I. Immunometabolism and HIV-1 pathogenesis: food for thought. Nat Rev Immunol. 2021 Jan;21(1):5-19. doi: 10.1038/s41577-020-0381-7. Epub 2020 Aug 6. PMID: 32764670.
Angin M et al. Metabolic plasticity of HIV-specific CD8+ T cells is associated with enhanced antiviral potential and natural control of HIV-1 infection. Nat Metab. 2019 Jul;1(7):704-716. doi: 10.1038/s42255-019-0081-4. Epub 2019 Jul 12. PMID: 32694646.
Valle-Casuso et al. Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4+ T Cells and Offers an Opportunity to Tackle Infection. Cell Metab. 2019 Mar 5;29(3):611-626.e5. doi: 10.1016/j.cmet.2018.11.015. PMID: 30581119.