Présentation
Séminaire
“Host cell colonization by Mycobacterium tuberculosis:
recent insights on the early onset”
présenté par Priscille Brodin
(Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille,
U1019 – UMR 8204 – CIIL – Centre d’Infection et d’Immunité de Lille)
Lundi 13 novembre à 12h00
Auditorium F. Jacob
Invitée par Guillaume Duménil & Jost Enninga
contacts: Anne Kongchanh (anne.kongchanh@pasteur.fr) &
Laurence Langlais ( laurence.langlais@pasteur.fr)
Abstract :
The highly successful pathogen Mycobacterium tuberculosis colonizes and replicates within different lung cell types and leads to the formation of a granuloma, the ultimate hallmark of most tuberculosis cases in adults. The interactions of pathogenic M. tuberculosis with the various cell types at early stages of bacillus colonization are still poorly understood, and the detailed molecular and cellular mechanisms are still unclear. Using a systems biology approach, we identified novel key host signaling pathways, which will be presented here. First, I will demonstrate how Arf1-dependent rearrangements of the actin cytoskeleton influence and restrict mycobacterial uptake in human epithelial cells. Second, I will show how M. tuberculosis counteracts the first line of acid defense in macrophages by co-opting cytokine-inducible SH2-containing protein (CISH) signaling.