Timeline

Marija Backovic

Group Leader

21 Oct 2023

project

Nanoparticles and extracellular vesicles as carriers of herpesvirus immunogens

21 Oct 2023

project

GOETHE: Glycoproteins and Entry into Host Cells – Structure and Function of the KSHV fusion machinery

18 Sep 2023

project

FURTHEST: Unraveling the Foamy Virus interactions with the host: insights into the molecular mechanisms of entry and neutralization

10 Jul 2023

publication

Qualitative monitoring of SARS-CoV-2 mRNA vaccination in humans using droplet microfluidics.

01 Jun 2023

publication

Estimated protection against COVID-19 based on predicted neutralisation titres from multiple antibody measurements in a longitudinal cohort, France, April 2020 to November 2021.

01 Apr 2023

publication

Neutralization of zoonotic retroviruses by human antibodies: Genotype-specific epitopes within the receptor-binding domain from simian foamy virus.

06 Mar 2023

publication

The crystal structure of a simian Foamy Virus receptor binding domain provides clues about entry into host cells.

23 Jan 2023

team

Structural biology of virus-host interactions

04 Jul 2022

publication

Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2.

17 Jun 2022

news

New publication – Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

15 Sep 2021

project

Foamy virus Env protein – where virus meets the cells and host immune system

01 Sep 2021

publication

Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling.

09 Jan 2021

project

PTR2020-353 ZOOFOAMENV – Host pathogens interactions in humans infected with zoonotic foamy viruses

02 Sep 2020

publication

A comparison of four serological assays for detecting anti–SARS-CoV-2 antibodies in human serum samples from different populations

01 Jul 2020

publication

Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV.

01 Jan 2020

publication

Absence of SARS-CoV-2 infection in cats and dogs in close contact with a cluster of COVID-19 patients in a veterinary campus.

06 Dec 2019

publication

X-ray Structures of the Post-fusion 6-Helix Bundle of the Human Syncytins and their Functional Implications.

01 Feb 2019

event

Virology Department : PhD Thesis Defense “Structural and functional studies on human syncytins -Insights into the molecular mechanisms of placental cell-cell fusion” with Catharina Ruigrok

01 Jan 2019

publication

Common characteristics and unique features: A comparison of the fusion machinery of the alphaherpesviruses Pseudorabies virus and Herpes simplex virus.

01 Jan 2018

publication

Structure-Function Dissection of Pseudorabies Virus Glycoprotein B Fusion Loops.

07 Nov 2017

publication

The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human αVβ3 Integrin via Steric Hindrance.

01 Jan 2016

publication

Stable Drosophila Cell Lines: An Alternative Approach to Exogenous Protein Expression.

01 Jan 2016

publication

Functional Characterization of Glycoprotein H Chimeras Composed of Conserved Domains of the Pseudorabies Virus and Herpes Simplex Virus 1 Homologs.

04 Jul 2015

project

Herpesvirus glycoproteins – entry and beyond

11 May 2015

team

Structural Virology

23 Apr 2015

publication

A replication defect of pseudorabies virus induced by targeted α-helix distortion in the syntaxin-like bundle of glycoprotein H (V275P) is corrected by an adjacent compensatory mutation (V271A).

12 Nov 2014

publication

Structure-based functional analyses of domains II and III of pseudorabies virus glycoprotein H.

03 Sep 2014

publication

The highly conserved proline at position 438 in pseudorabies virus gH is important for regulation of membrane fusion.

02 Jan 2012

publication

Virus entry: old viruses, new receptors.

13 Dec 2010

publication

Structure of a core fragment of glycoprotein H from pseudorabies virus in complex with antibody.

24 Jan 2010

publication

Efficient method for production of high yields of Fab fragments in Drosophila S2 cells.

24 Feb 2009

publication

Structure of a trimeric variant of the Epstein-Barr virus glycoprotein B.

01 Jan 2009

publication

Analysis of Epstein-Barr virus glycoprotein B functional domains via linker insertion mutagenesis.

10 Nov 2007

publication

Characterization of EBV gB indicates properties of both class I and class II viral fusion proteins.

01 Sep 2007

publication

Hydrophobic residues that form putative fusion loops of Epstein-Barr virus glycoprotein B are critical for fusion activity.

01 Feb 2004

publication

Use of NMR to study serpin function.

01 May 2002

publication

Structural similarity of the covalent complexes formed between the serpin plasminogen activator inhibitor-1 and the arginine-specific proteinases trypsin, LMW u-PA, HMW u-PA, and t-PA: use of site-specific fluorescent probes of local environment.

01 Jan 2002

publication

A little guide for advanced search:

Timeline

Nanoparticles and extracellular vesicles as carriers of herpesvirus immunogens

GOETHE: Glycoproteins and Entry into Host Cells – Structure and Function of the KSHV fusion machinery

FURTHEST: Unraveling the Foamy Virus interactions with the host: insights into the molecular mechanisms of entry and neutralization

Qualitative monitoring of SARS-CoV-2 mRNA vaccination in humans using droplet microfluidics.

Estimated protection against COVID-19 based on predicted neutralisation titres from multiple antibody measurements in a longitudinal cohort, France, April 2020 to November 2021.

Neutralization of zoonotic retroviruses by human antibodies: Genotype-specific epitopes within the receptor-binding domain from simian foamy virus.

The crystal structure of a simian Foamy Virus receptor binding domain provides clues about entry into host cells.

Structural biology of virus-host interactions

Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2.

New publication – Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

Foamy virus Env protein – where virus meets the cells and host immune system

Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling.

PTR2020-353 ZOOFOAMENV – Host pathogens interactions in humans infected with zoonotic foamy viruses

A comparison of four serological assays for detecting anti–SARS-CoV-2 antibodies in human serum samples from different populations

Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV.

Absence of SARS-CoV-2 infection in cats and dogs in close contact with a cluster of COVID-19 patients in a veterinary campus.

X-ray Structures of the Post-fusion 6-Helix Bundle of the Human Syncytins and their Functional Implications.

Virology Department : PhD Thesis Defense “Structural and functional studies on human syncytins -Insights into the molecular mechanisms of placental cell-cell fusion” with Catharina Ruigrok

Common characteristics and unique features: A comparison of the fusion machinery of the alphaherpesviruses Pseudorabies virus and Herpes simplex virus.

Structure-Function Dissection of Pseudorabies Virus Glycoprotein B Fusion Loops.

The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human αVβ3 Integrin via Steric Hindrance.

Stable Drosophila Cell Lines: An Alternative Approach to Exogenous Protein Expression.

Functional Characterization of Glycoprotein H Chimeras Composed of Conserved Domains of the Pseudorabies Virus and Herpes Simplex Virus 1 Homologs.

Herpesvirus glycoproteins – entry and beyond

Structural Virology

A replication defect of pseudorabies virus induced by targeted α-helix distortion in the syntaxin-like bundle of glycoprotein H (V275P) is corrected by an adjacent compensatory mutation (V271A).

Structure-based functional analyses of domains II and III of pseudorabies virus glycoprotein H.

The highly conserved proline at position 438 in pseudorabies virus gH is important for regulation of membrane fusion.

Virus entry: old viruses, new receptors.

Structure of a core fragment of glycoprotein H from pseudorabies virus in complex with antibody.

Efficient method for production of high yields of Fab fragments in Drosophila S2 cells.

Structure of a trimeric variant of the Epstein-Barr virus glycoprotein B.

Analysis of Epstein-Barr virus glycoprotein B functional domains via linker insertion mutagenesis.

Characterization of EBV gB indicates properties of both class I and class II viral fusion proteins.

Hydrophobic residues that form putative fusion loops of Epstein-Barr virus glycoprotein B are critical for fusion activity.

Use of NMR to study serpin function.

Structural similarity of the covalent complexes formed between the serpin plasminogen activator inhibitor-1 and the arginine-specific proteinases trypsin, LMW u-PA, HMW u-PA, and t-PA: use of site-specific fluorescent probes of local environment.

Insight into Residues Critical for Antithrombin Function from an Expanded Database of Sequences That Includes Frog, Turtle and Ostrich Antithrombins.