Timeline

Saaid Safieddine

Permanent Researcher

03 Aug 2024

publication

A free intravesicular C-terminal of otoferlin is essential for synaptic vesicle docking and fusion at auditory inner hair cell ribbon synapses.

19 Jul 2024

publication

In utero adeno-associated virus (AAV)-mediated gene delivery targeting sensory and supporting cells in the embryonic mouse inner ear.

09 Jan 2024

publication

Extended time frame for restoring inner ear function through gene therapy in Usher1G preclinical model

01 Jun 2023

publication

Recent advances and future challenges in gene therapy for hearing loss.

12 May 2023

publication

Deafness: from genetic architecture to gene therapy

29 Jan 2023

publication

Towards the Clinical Application of Gene Therapy for Genetic Inner Ear Diseases.

22 Dec 2022

publication

The SNARE protein SNAP-25 is required for normal exocytosis at auditory hair cell ribbon synapses.

13 Aug 2021

team

Technologies and Gene Therapy for Deafness

01 Dec 2019

publication

[Congenital deafness forms: progressing toward gene therapy?].

15 Nov 2019

publication

Hair Cell Afferent Synapses: Function and Dysfunction.

01 Jun 2019

publication

Hearing Protection, Restoration, and Regeneration: An Overview of Emerging Therapeutics for Inner Ear and Central Hearing Disorders.

01 May 2019

publication

Viral Transfer of Mini-Otoferlins Partially Restores the Fast Component of Exocytosis and Uncovers Ultrafast Endocytosis in Auditory Hair Cells of Otoferlin Knock-Out Mice.

05 Mar 2019

publication

Dual AAV-mediated gene therapy restores hearing in a DFNB9 mouse model.

01 Oct 2018

publication

[Gene therapy progress: hopes for Usher syndrome].

01 Oct 2018

publication

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation.

01 Aug 2018

publication

Clarin-1 gene transfer rescues auditory synaptopathy in model of Usher syndrome.

07 Nov 2017

publication

Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses.

05 Sep 2017

publication

Local gene therapy durably restores vestibular function in a mouse model of Usher syndrome type 1G.

14 Apr 2017

event

“Tailoring AAV for Gene Delivery and Gene Therapy” – Dr Deniz Dalkara

15 Mar 2017

publication

Different Ca V 1.3 Channel Isoforms Control Distinct Components of the Synaptic Vesicle Cycle in Auditory Inner Hair Cells

05 Nov 2015

publication

Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes.

13 Aug 2014

publication

Exocytotic Machineries of Vestibular Type I and Cochlear Ribbon Synapses Display Similar Intrinsic Otoferlin-Dependent Ca2+ Sensitivity But a Different Coupling to Ca2+ Channels

01 Oct 2013

publication

[Gene therapy for human hearing loss: challenges and promises].

01 Jan 2012

publication

The auditory hair cell ribbon synapse: from assembly to function.

06 Oct 2010

publication

Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells.

01 Dec 2009

publication

Myosin VI is required for the proper maturation and function of inner hair cell ribbon synapses.

26 Aug 2009

publication

Otoferlin is critical for a highly sensitive and linear calcium-dependent exocytosis at vestibular hair cell ribbon synapses.

15 Oct 2008

publication

αII-βV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells

20 Feb 2008

publication

Calcium- and otoferlin-dependent exocytosis by immature outer hair cells.

01 Jan 2008

publication

[Chapter 8] Mouse Models for Human Hereditary Deafness

20 Oct 2006

publication

Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse.

01 Jun 2002

publication

Identification of a novel SNAP25 interacting protein (SIP30).

01 May 2002

publication

Cysteine-string protein in inner hair cells of the organ of Corti: synaptic expression and upregulation at the onset of hearing.

01 Jan 2002

publication

Vesicle targeting in hair cells.

15 Nov 2000

publication

Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex

22 Sep 2000

publication

Unconventional Myosin VIIA Is a Novel A-kinase-anchoring Protein

11 Apr 2000

publication

KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway.

01 Jan 1992

publication

Triple Immunofluorescence Evidence for the Coexistence of Acetylcholine, Enkephalins and Calcitonin Gene-related Peptide Within Efferent (Olivocochlear) Neurons of Rats and Guinea-pigs.

A little guide for advanced search:

A free intravesicular C-terminal of otoferlin is essential for synaptic vesicle docking and fusion at auditory inner hair cell ribbon synapses.

In utero adeno-associated virus (AAV)-mediated gene delivery targeting sensory and supporting cells in the embryonic mouse inner ear.

Extended time frame for restoring inner ear function through gene therapy in Usher1G preclinical model

Recent advances and future challenges in gene therapy for hearing loss.

Deafness: from genetic architecture to gene therapy

Towards the Clinical Application of Gene Therapy for Genetic Inner Ear Diseases.

The SNARE protein SNAP-25 is required for normal exocytosis at auditory hair cell ribbon synapses.

Technologies and Gene Therapy for Deafness

[Congenital deafness forms: progressing toward gene therapy?].

Hair Cell Afferent Synapses: Function and Dysfunction.

Hearing Protection, Restoration, and Regeneration: An Overview of Emerging Therapeutics for Inner Ear and Central Hearing Disorders.

Viral Transfer of Mini-Otoferlins Partially Restores the Fast Component of Exocytosis and Uncovers Ultrafast Endocytosis in Auditory Hair Cells of Otoferlin Knock-Out Mice.

Dual AAV-mediated gene therapy restores hearing in a DFNB9 mouse model.

[Gene therapy progress: hopes for Usher syndrome].

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation.

Clarin-1 gene transfer rescues auditory synaptopathy in model of Usher syndrome.

Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses.

Local gene therapy durably restores vestibular function in a mouse model of Usher syndrome type 1G.

“Tailoring AAV for Gene Delivery and Gene Therapy” – Dr Deniz Dalkara

Different Ca V 1.3 Channel Isoforms Control Distinct Components of the Synaptic Vesicle Cycle in Auditory Inner Hair Cells

Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes.

Exocytotic Machineries of Vestibular Type I and Cochlear Ribbon Synapses Display Similar Intrinsic Otoferlin-Dependent Ca2+ Sensitivity But a Different Coupling to Ca2+ Channels

[Gene therapy for human hearing loss: challenges and promises].

The auditory hair cell ribbon synapse: from assembly to function.

Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells.

Myosin VI is required for the proper maturation and function of inner hair cell ribbon synapses.

Otoferlin is critical for a highly sensitive and linear calcium-dependent exocytosis at vestibular hair cell ribbon synapses.

αII-βV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells

Calcium- and otoferlin-dependent exocytosis by immature outer hair cells.

[Chapter 8] Mouse Models for Human Hereditary Deafness

Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse.

Identification of a novel SNAP25 interacting protein (SIP30).

Cysteine-string protein in inner hair cells of the organ of Corti: synaptic expression and upregulation at the onset of hearing.

Vesicle targeting in hair cells.

Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex

Unconventional Myosin VIIA Is a Novel A-kinase-anchoring Protein

KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway.

Triple Immunofluorescence Evidence for the Coexistence of Acetylcholine, Enkephalins and Calcitonin Gene-related Peptide Within Efferent (Olivocochlear) Neurons of Rats and Guinea-pigs.