Timeline

Arnaud Blondel
Group Leader
09 Mar 2020
event

Cancelled – Séminaire: Bridging chemistry and biology in drug discovery: Filling the gap with artificial intelligence.

Read more
27 Feb 2018
project

Discovery of allosteric modulators specifically targeting α5-containing nAChRs. (ANR-Nicofive)

Read more
16 Oct 2015
project

AEGIS (Accelerated Early staGe drug dIScovery)

Read more
16 Jul 2015
team

Group: Dynamics & Drug Design

Read more
07 Jul 2015
project

Bip:Bip

Read more
02 Jul 2015
project

Chagas

Read more
13 May 2015
publication

The catalytic domains of Clostridium sordellii lethal toxin and related large clostridial glucosylating toxins specifically recognize the negatively charged phospholipids phosphatidylserine and phosphatidic acid

Read more
11 May 2015
team

Structural Bioinformatics

Read more
21 Mar 2015
publication

Identification of binding sites and favorable ligand binding moieties by virtual screening and self-organizing map analysis

Read more
26 Dec 2014
publication

An automatic tool to analyze and cluster macromolecular conformations based on self-organizing maps

Read more
25 Oct 2014
publication

Principal Component Analysis reveals correlation of cavities evolution and functional motions in proteins

Read more
15 Jan 2014
publication

Functional motions modulating VanA ligand binding unraveled by self-organizing maps

Read more
04 Jun 2013
publication

Identification of cinnamic acid derivatives as novel antagonists of the prokaryotic proton-gated ion channel GLIC

Read more
16 Apr 2013
publication

Combined approaches for drug design points the way to novel proline racemase inhibitor candidates to fight Chagas’ disease

Read more
21 Mar 2011
publication

Mechanism of reactant and product dissociation from the anthrax edema factor: a locally enhanced sampling and steered molecular dynamics study

Read more
01 Oct 2010
publication

Activation of the edema factor of Bacillus anthracis by calmodulin: evidence of an interplay between the EF-calmodulin interaction and calcium binding

Read more
07 Jun 2010
publication

Use of allostery to identify inhibitors of calmodulin-induced activation of Bacillus anthracis edema factor

Read more
01 Dec 2009
publication

ATP conformations and ion binding modes in the active site of anthrax edema factor: a computational analysis

Read more
18 Feb 2009
publication

Dynamics and energetics: a consensus analysis of the impact of calcium on EF-CaM protein complex

Read more
01 Jun 2008
publication

The conformational plasticity of calmodulin upon calcium complexation gives a model of its interaction with the oedema factor of Bacillus anthracis

Read more
01 May 2004
publication

Ensemble variance in free energy calculations by thermodynamic integration: theory, optimal “Alchemical” path, and practical solutions

Read more
01 Jan 2004
publication

Effect of multiple symmetries on the association of R67 DHFR subunits bearing interfacial complementing mutations

Read more