Timeline

Christine Petit
Head of Structure
10 Jul 2017
publication

Conformational switch of harmonin, a submembrane scaffold protein of the hair cell mechanoelectrical transduction machinery

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27 Jul 2016
publication

An innovative strategy for the molecular diagnosis of Usher syndrome identifies causal biallelic mutations in 93% of European patients

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09 Jun 2016
software

TissueMiner

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27 Jan 2016
publication

High frequency of OTOF mutations in Chinese infants with congenital auditory neuropathy spectrum disorder

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11 Jan 2016
publication

Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth

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19 Nov 2015
project

RHU LIGHT4DEAF

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19 Nov 2015
project

HearDeafTreat Hearing and deafness: molecular mechanisms and therapeutic approaches

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14 Nov 2015
publication

A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells

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01 Nov 2015
publication

Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes

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30 Oct 2015
project

LABEX LIFESENSES

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30 Oct 2015
project

ERC-2011-AdG HAIRBUNDLE

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19 Aug 2015
publication

EPS8L2 is a new causal gene for childhood onset autosomal recessive progressive hearing loss

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03 Jul 2015
project

Human and mouse hereditary deafness

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03 Jun 2015
publication

The tip-link molecular complex of the auditory mechano-electrical transduction machinery

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18 May 2015
publication

Mutations in apoptosis-inducing factor cause X-linked recessive auditory neuropathy spectrum disorder

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12 May 2015
project

From genes to the molecular physiology of hearing

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12 May 2015
project

Human and mouse hereditary deafness

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23 Mar 2015
publication

Whole exome sequencing identifies mutations in Usher syndrome genes in profoundly deaf Tunisian patients

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15 Feb 2015
publication

Diversity of the causal genes in hearing impaired Algerian individuals identified by whole exome sequencing

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16 Sep 2014
team

Genetics & Physiology of Hearing

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13 Aug 2014
publication

Exocytotic machineries of vestibular type I and cochlear ribbon synapses display similar intrinsic otoferlin-dependent Ca2+ sensitivity but a different coupling to Ca2+ channels

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12 Aug 2014
publication

Targeted high-throughput sequencing identifies pathogenic mutations in KCNQ4 in two large Chinese families with autosomal dominant hearing loss

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29 Jul 2014
publication

Specific aspects of consanguinity: some examples from the Tunisian population

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25 Jun 2014
publication

Genetics of auditory mechano-electrical transduction

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17 Jun 2014
publication

The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells

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13 Jun 2014
publication

Whole exome sequencing identifies new causative mutations in Tunisian families with non-syndromic deafness

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11 Jun 2014
publication

An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells

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17 Apr 2014
publication

EPS8, encoding an actin-binding protein of cochlear hair cell stereocilia, is a new causal gene for autosomal recessive profound deafness

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20 Mar 2014
publication

The retinal phenotype of Usher syndrome: pathophysiological insights from animal models

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18 Oct 2013
publication

[Gene therapy for human hearing loss: challenges and promises]

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01 Jul 2013
publication

Auditory hair cell centrioles undergo confined Brownian motion throughout the developmental migration of the kinocilium

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23 May 2013
publication

The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route

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01 Jan 2013
publication

Cadherin defects in inherited human diseases

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07 Jun 2012
publication

Defect in the gene encoding the EAR/EPTP domain-containing protein TSPEAR causes DFNB98 profound deafness

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01 Jan 2012
publication

The auditory hair cell ribbon synapse: from assembly to function

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21 Mar 2011
publication

Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia

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01 Feb 2011
publication

Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane

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01 Nov 2010
publication

[Stem cell therapy in the inner ear: recent achievements and prospects]

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16 Jul 2010
publication

Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids

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28 May 2010
publication

Wrapping up stereocilia rootlets

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01 Apr 2010
publication

Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape

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01 Jan 2010
publication

Cadherins as targets for genetic diseases

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01 Nov 2009
publication

Harmonin-b, an actin-binding scaffold protein, is involved in the adaptation of mechanoelectrical transduction by sensory hair cells

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28 Oct 2009
publication

Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins

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10 Sep 2009
publication

Myosin VI is required for the proper maturation and function of inner hair cell ribbon synapses

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26 May 2009
publication

Linking genes underlying deafness to hair-bundle development and function

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01 May 2009
publication

Vezatin, an integral membrane protein of adherens junctions, is required for the sound resilience of cochlear hair cells

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08 Oct 2008
publication

Stereocilin-deficient mice reveal the origin of cochlear waveform distortions

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16 Sep 2008
publication

alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells

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13 Mar 2008
publication

A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth

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01 Jan 2008
publication

Mouse models for human hereditary deafness

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31 Jul 2007
publication

Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions

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13 Jun 2007
publication

Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning

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20 Oct 2006
publication

Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse

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25 Jun 2006
publication

Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy

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10 Jan 2006
publication

From deafness genes to hearing mechanisms: harmony and counterpoint

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21 Nov 2005
publication

Usherin, the defective protein in Usher syndrome type IIA, is likely to be a component of interstereocilia ankle links in the inner ear sensory cells

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15 Oct 2005
publication

Usher I syndrome: unravelling the mechanisms that underlie the cohesion of the growing hair bundle in inner ear sensory cells

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01 Aug 2005
publication

[Usher syndrome type I and the differentiation of inner ear sensory cells’ hair bundles]

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01 Jul 2005
publication

PHR1, an integral membrane protein of the inner ear sensory cells, directly interacts with myosin 1c and myosin VIIa

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01 May 2005
publication

Initial characterization of kinocilin, a protein of the hair cell kinocilium

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15 Apr 2005
publication

Cadherin 23 is a component of the transient lateral links in the developing hair bundles of cochlear sensory cells

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08 Dec 2004
publication

Interactions in the network of Usher syndrome type 1 proteins

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08 Dec 2004
publication

Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly

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15 Sep 2004
publication

Memorial lecture-hereditary sensory defects: from genes to pathogenesis

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15 Apr 2004
publication

Unconventional myosin VIIa and vezatin, two proteins crucial for Listeria entry into epithelial cells

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01 Mar 2004
publication

[Hereditary deafness: molecular genetics]

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20 Feb 2004
publication

Expression of the connexin43- and connexin45-encoding genes in the developing and mature mouse inner ear

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01 Oct 2003
publication

DFNB40, a recessive form of sensorineural hearing loss, maps to chromosome 22q11.21-12.1

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01 Mar 2003
publication

Usher syndrome type I G (USH1G) is caused by mutations in the gene encoding SANS, a protein that associates with the USH1C protein, harmonin

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01 Jul 2002
publication

Targeted ablation of connexin26 in the inner ear epithelial gap junction network causes hearing impairment and cell death

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01 Jun 2002
publication

A subtracted cDNA library from the zebrafish (Danio rerio) embryonic inner ear

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19 Apr 2002
publication

Anosmin-1, defective in the X-linked form of Kallmann syndrome, promotes axonal branch formation from olfactory bulb output neurons

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18 Apr 2002
publication

MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes

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12 Mar 2002
publication

A novel locus for Usher syndrome type I, USH1G, maps to chromosome 17q24-25

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01 Mar 2002
publication

DFNB31, a recessive form of sensorineural hearing loss, maps to chromosome 9q32-34

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01 Jan 2002
publication

DFNB21

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01 Jan 2002
publication

DFNB9

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