The surface complexes of many enveloped viruses are perfect targets for therapeutic design. Our group combines structural biology, computational biology, biophysics and virology techniques to study viral surface complexes and develop antiviral therapies. We have a particular interest in understanding the mechanisms of entry of large DNA viruses (poxviruses and related viruses), in the mechanisms of action of antibodies that clear the infection, whether neutralising or not, and in using this knowledge to develop novel therapies.
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Transversal Project
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Publications
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2025Structural basis of poxvirus fusion regulation and anti-A16/G9 antibody-mediated neutralization and protection., Cell 2025 Aug; (): .
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2025Modulation of SARS-CoV-2 spike binding to ACE2 through conformational selection., Nat Nanotechnol 2025 Jul; 20(7): 926-934.
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2025Monkeypox Virus Infection Stimulates a More Robust and Durable Neutralizing Antibody Response Compared to Modified Vaccinia Virus Ankara Vaccination., J Infect Dis 2025 Apr; 231(4): 1069-1073.
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2025On the role of VP3-PI3P interaction in birnavirus endosomal membrane targeting., Elife 2025 Mar; 13(): .
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2025Disruption of deoxyribonucleotide triphosphate biosynthesis leads to RAS proto-oncogene activation and perturbation of mitochondrial metabolism., J Biol Chem 2025 Feb; 301(2): 108117.
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2025Antiviral activity of tecovirimat against monkeypox virus clades 1a, 1b, 2a, and 2b., Lancet Infect Dis 2025 Mar; 25(3): e126-e127.
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2025Structural insights into tecovirimat antiviral activity and poxvirus resistance., Nat Microbiol 2025 Mar; 10(3): 734-748.
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2025Puumala orthohantavirus: prevalence, biology, disease, animal models and recent advances in therapeutics development and structural biology., Front Immunol 2025 ; 16(): 1575112.
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2024MECHANISMS OF TECOVIRIMAT ANTIVIRAL ACTIVITY AND POXVIRUS RESISTANCE., Res Sq 2024 Sep; (): .
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2024Broad sarbecovirus neutralization by combined memory B cell antibodies to ancestral SARS-CoV-2., iScience 2024 Jul; 27(7): 110354.
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