The surface complexes of many enveloped viruses are perfect targets for therapeutic design. Our group combines structural biology, computational biology, biophysics and virology techniques to study viral surface complexes and develop antiviral therapies. We have a particular interest in understanding the mechanisms of entry of large DNA viruses (poxviruses and related viruses), in the mechanisms of action of antibodies that clear the infection, whether neutralising or not, and in using this knowledge to develop novel therapies.
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2024MECHANISMS OF TECOVIRIMAT ANTIVIRAL ACTIVITY AND POXVIRUS RESISTANCE., Res Sq 2024 Sep; (): .
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2024Production and Purification of Hantavirus Glycoproteins in Drosophila melanogaster S2 Cells., Methods Mol Biol 2024 ; 2762(): 3-16.
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2023Neutralization Determinants on Poxviruses, Viruses, 2023, 15 (12), pp.2396. ⟨10.3390/v15122396⟩.
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2023Two point mutations in protocadherin-1 disrupt hantavirus recognition and afford protection against lethal infection., Nat Commun 2023 Jul; 14(1): 4454.
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2023Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody., Sci Transl Med 2023 Jun; 15(700): eadg1855.
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2023Structure, function, and evolution of the Orthobunyavirus membrane fusion glycoprotein., Cell Rep 2023 Mar; 42(3): 112142.
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2023Antigenic mapping and functional characterization of human New World hantavirus neutralizing antibodies., Elife 2023 Mar; 12(): .
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2023A Search for Tick-Associated, Bronnoya-like Virus Spillover into Sheep, Microorganisms, 2023, 11 (1), pp.209. ⟨10.3390/microorganisms11010209⟩.
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2022Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2., J Exp Med 2022 Jul; 219(7): .
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2022Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses., Sci Transl Med 2022 Mar; 14(636): eabl5399.
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