The work of our group focuses on the development of integrated, quantitative imaging approaches combining wetlab experiments, microscopy/instrumentation and image analysis. Our main focus is on single RNA imaging to study RNA regulation across several spatial scales. Biological question come from both internal projects and from our network of collaborations.
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Transversal Project
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Publications
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2024pyHiM: a new open-source, multi-platform software package for spatial genomics based on multiplexed DNA-FISH imaging., Genome Biol 2024 Feb; 25(1): 47.
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2023An interactive murine single-cell atlas of the lung responses to radiation injury., Nat Commun 2023 Apr; 14(1): 2445.
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2023A specific molecular signature in SARS-CoV-2-infected kidney biopsies., JCI Insight 2023 Mar; 8(5): .
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2023PointFISH: Learning Point Cloud Representations for RNA Localization Patterns, Computer Vision – ECCV 2022 Workshops.
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2023Excessive self-grooming, gene dysregulation and imbalance between the striosome and matrix compartments in the striatum of Shank3 mutant mice., Front Mol Neurosci 2023 ; 16(): 1139118.
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2022HT-smFISH: a cost-effective and flexible workflow for high-throughput single-molecule RNA imaging., Nat Protoc 2022 Oct; (): .
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2022FISH-quant v2: a scalable and modular tool for smFISH image analysis., RNA 2022 06; 28(6): 786-795.
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2022Sensitive visualization of SARS-CoV-2 RNA with CoronaFISH., Life Sci Alliance 2022 Apr; 5(4): .
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2022piRNAs initiate transcriptional silencing of spermatogenic genes during C. elegans germline development., Dev Cell 2022 Jan; 57(2): 180-196.e7.
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2021The kinesin KIF1C transports APC-dependent mRNAs to cell protrusions., RNA 2021 Dec; 27(12): 1528-1544.
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