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© Therese Couderc, Marc Lecuit
Publication : Open forum infectious diseases

Viral RNA Degradation Makes Urine a Challenging Specimen for Detection of Japanese Encephalitis Virus in Patients With Suspected CNS Infection

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Open forum infectious diseases - 06 Feb 2019

Bharucha T, Sengvilaipaseuth O, Seephonelee M, Vongsouvath M, Vongsouvath M, Rattanavong S, Piorkowski G, Lecuit M, Gorman C, Pommier JD, Garson JA, Newton PN, de Lamballerie X, Dubot-Pérès A

Link to Pubmed [PMID] – 30882014

Open Forum Infect Dis 2019 Mar;6(3):ofz048

Japanese encephalitis virus (JEV) is a leading cause of central nervous system (CNS) infections in Asia and results in significant morbidity and mortality. JEV RNA is rarely detected in serum or cerebrospinal fluid (CSF), and diagnosis of JEV infection is usually based on serological tests that are frequently difficult to interpret. Unlike serum or CSF, urine is relatively easy to obtain, but, to date, there has been minimal work on the feasibility of testing urine for JEV RNA.

https://www.ncbi.nlm.nih.gov/pubmed/30882014