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© Research
Publication : Antimicrobial agents and chemotherapy

Variants of the Klebsiella pneumoniae OKP chromosomal beta-lactamase are divided into two main groups, OKP-A and OKP-B

Team: Microbial Evolutionary Genomics
Team: Enteric Bacterial Pathogens
Member: Sylvain Brisse
Member: Francois-Xavier Weill
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antimicrobial agents and chemotherapy - 01 Dec 2005

Fevre C, Passet V, Weill FX, Grimont PA, Brisse S

Link to Pubmed [PMID] – 16304190

Antimicrob. Agents Chemother. 2005 Dec;49(12):5149-52

Two bla(OKP) subgroups were found, diverging by 4.2%. Subgroups bla(OKP-A) (10 enzyme variants, pIs from 7.1 to 8.3) and bla(OKP-B) (11 variants, pI 7.1) showed similar antibiotic susceptibilities. Sequencing of rpoB, gyrA, and mdh demonstrated a concordant subdivision of Klebsiella pneumoniae phylogenetic group KpII into two subgroups, KpII-A and KpII-B.