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© Research
Publication : Bioinformatics (Oxford, England)

Using tertiary structure for the computation of highly accurate multiple RNA alignments with the SARA-Coffee package

Team: Bioinformatics and Biostatistics HUB
Team: Expertise group : SysBio – System Bioinformatics
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Bioinformatics (Oxford, England) - 28 Feb 2013

Kemena C, Bussotti G, Capriotti E, Marti-Renom MA, Notredame C

Link to Pubmed [PMID] – 23449094

Bioinformatics 2013 May;29(9):1112-9

Aligning RNAs is useful to search for homologous genes, study evolutionary relationships, detect conserved regions and identify any patterns that may be of biological relevance. Poor levels of conservation among homologs, however, make it difficult to compare RNA sequences, even when considering closely evolutionary related sequences.