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© Research
Publication : Clinical journal of the American Society of Nephrology : CJASN

Urinary procollagen III aminoterminal propeptide (PIIINP): a fibrotest for the nephrologist

Team: Biological Image Analysis
Member: Jean-Christophe Olivo-Marin
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Clinical journal of the American Society of Nephrology : CJASN - 14 Jan 2010

Ghoul BE, Squalli T, Servais A, Elie C, Meas-Yedid V, Trivint C, Vanmassenhove J, Grünfeld JP, Olivo-Marin JC, Thervet E, Noël LH, Prié D, Fakhouri F

Link to Pubmed [PMID] – 20089486

Clin J Am Soc Nephrol 2010 Feb;5(2):205-10

Kidney biopsy (KB), to date the only tool for the evaluation of renal fibrosis, carries specific risks, and its relevance is limited by the small size of renal parenchyma assessed. Thus, a noninvasive alternative to KB is required. Collagen type III amino-terminal propeptide (PIIINP) is a degradation product of collagen type III, the increase of which may reflect an ongoing fibrotic process.