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© Therese Couderc, Marc Lecuit
Publication : The American journal of tropical medicine and hygiene

Unmasking leprosy: an unusual immune reconstitution inflammatory syndrome in a patient infected with human immunodeficiency virus

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The American journal of tropical medicine and hygiene - 01 Jul 2010

Bussone G, Charlier C, Bille E, Caux F, Lévy A, Viard JP, Lecuit M, Lortholary O

Link to Pubmed [PMID] – 20595470

Am. J. Trop. Med. Hyg. 2010 Jul;83(1):13-4

Immune reconstitution inflammatory syndrome (IRIS) has become a frequent and potentially severe complication after initiation of following antiretroviral therapy (ART) in patients infected with human immunodeficiency virus (HIV). IRIS can unmask a previously clinically silent infection, such as tuberculosis, as recently described for Mycobacterium infections. We describe a case in a patient from Côte d’Ivoire living in France in whom skin papular lesions developed after initiation of ART. These lesions were associated with microbiologically proven leprosy. Thus, latent leprosy can appear as IRIS, and leprosy-associated IRIS should be considered in HIV-infected patients from areas endemic for leprosy.

http://www.ncbi.nlm.nih.gov/pubmed/20595470