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© Research
Publication : Genome biology

Understanding rare and common diseases in the context of human evolution

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Genome biology - 07 Nov 2016

Quintana-Murci L

Link to Pubmed [PMID] – 27821149

Genome Biol. 2016 Nov;17(1):225

The wealth of available genetic information is allowing the reconstruction of human demographic and adaptive history. Demography and purifying selection affect the purge of rare, deleterious mutations from the human population, whereas positive and balancing selection can increase the frequency of advantageous variants, improving survival and reproduction in specific environmental conditions. In this review, I discuss how theoretical and empirical population genetics studies, using both modern and ancient DNA data, are a powerful tool for obtaining new insight into the genetic basis of severe disorders and complex disease phenotypes, rare and common, focusing particularly on infectious disease risk.

https://www.ncbi.nlm.nih.gov/pubmed/27821149