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Evolutionary diversification of the HAP2 membrane insertion motifs to drive gamete fusion across eukaryotes

International Committee on Systematics of Prokaryotes Subcommittee on the Taxonomy of Leptospiraceae. Minutes of the closed meeting, 28 November 2017, Palmerston North, New Zealand

© Pierre Gounon

Entrée de Listeria dans une cellule épithéliale (Grossissement X 10000). Image colorisée.

Publication : Trends in cell biology

Ubiquitin, SUMO, and NEDD8: Key Targets of Bacterial Pathogens

Team: Bacteria-Cell Interactions

Member: Pascale Cossart

Scientific Fields

Diseases

Organisms

Applications

Technique

Published in Trends in cell biology - 11 Aug 2018

Ribet D, Cossart P

Link to Pubmed [PMID] – 30107971

Trends Cell Biol. 2018 Aug;

Manipulation of host protein post-translational modifications (PTMs) is used by various pathogens to interfere with host cell functions. Among these modifications, ubiquitin (UBI) and ubiquitin-like proteins (UBLs) constitute key targets because they are regulators of pathways essential for the host cell. In particular, these PTM modifiers control pathways that have been described as crucial for infection such as pathogen entry, replication, propagation, or detection by the host. Although bacterial pathogens lack eucaryotic-like UBI or UBL systems, many of them produce proteins that specifically interfere with these host PTMs during infection. In this review we discuss the different mechanisms used by bacteria to interfere with host UBI and the two UBLs, SUMO and NEDD8.

Published on: 11 Aug 2018