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© Research
Publication : Therapeutic drug monitoring

Therapeutic drug monitoring of voriconazole after intravenous administration in infants and children with primary immunodeficiency

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Therapeutic drug monitoring - 01 Aug 2011

Gerin M, Mahlaoui N, Elie C, Lanternier F, Bougnoux ME, Blanche S, Lortholary O, Jullien V

Link to Pubmed [PMID] – 21743382

Ther Drug Monit 2011 Aug;33(4):464-6

OBJECTIVE: A voriconazole trough concentration (Ctrough) <1 mg/L is associated with a higher risk of treatment failure. The aim of this work was to describe the probability of not achieving this target concentration in infants and children receiving intravenous voriconazole.

METHODS: Voriconazole trough concentrations obtained during routine therapeutic drug monitoring over a 5-year period were collected retrospectively from infants and children receiving intravenous voriconazole for presumed or proven invasive fungal infections.

RESULTS: Sixty-two trough concentrations were obtained from 6 infants and 10 children. The risk of a Ctrough 1 mg/L, compared with the currently recommended 14-mg/kg regimen.

CONCLUSIONS: Routine therapeutic drug monitoring is potentially helpful in infants and children receiving voriconazole, even intravenously.

http://www.ncbi.nlm.nih.gov/pubmed/21743382