Lien vers Pubmed [PMID] – 21743382
Ther Drug Monit 2011 Aug;33(4):464-6
OBJECTIVE: A voriconazole trough concentration (Ctrough) <1 mg/L is associated with a higher risk of treatment failure. The aim of this work was to describe the probability of not achieving this target concentration in infants and children receiving intravenous voriconazole.
METHODS: Voriconazole trough concentrations obtained during routine therapeutic drug monitoring over a 5-year period were collected retrospectively from infants and children receiving intravenous voriconazole for presumed or proven invasive fungal infections.
RESULTS: Sixty-two trough concentrations were obtained from 6 infants and 10 children. The risk of a Ctrough 1 mg/L, compared with the currently recommended 14-mg/kg regimen.
CONCLUSIONS: Routine therapeutic drug monitoring is potentially helpful in infants and children receiving voriconazole, even intravenously.http://www.ncbi.nlm.nih.gov/pubmed/21743382