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© Research
Publication : Gut

The regenerating family member 3 β instigates IL-17A-mediated neutrophil recruitment downstream of NOD1/2 signalling for controlling colonisation resistance independently of microbiota community structure

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Gut - 02 Oct 2018

Waldschmitt N, Kitamoto S, Secher T, Zacharioudaki V, Boulard O, Floquet E, Delacre M, Lamas B, Pham HP, Six A, Richard ML, Dagorn JC, Eberl G, Langella P, Chatel JM, Ryffel B, Iovanna JL, Poulin LF, Sokol H, Kamada N, Chamaillard M

Link to Pubmed [PMID] – 30279238

Gut 2019 07;68(7):1190-1199

Loss of the Crohn’s disease predisposing gene results in an intestinal microenvironment conducive for colonisation by attaching-and-effacing enteropathogens. However, it remains elusive whether it relies on the intracellular recruitment of the serine-threonine kinase RIPK2 by NOD2, a step that is required for its activation of the transcription factor NF-κB.

https://www.ncbi.nlm.nih.gov/pubmed/30279238