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© Institut Pasteur
Macrophages et lymphocytes de souris. Image colorisée.
Publication : European journal of immunology

The majority of “natural” immunoglobulin-secreting cells are short-lived and the progeny of cycling lymphocytes

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in European journal of immunology - 01 Jun 1987

Lévy M, Vieira P, Coutinho A, Freitas A

Link to Pubmed [PMID] – 3297735

Eur. J. Immunol. 1987 Jun;17(6):849-54

Treatment of mice with hydroxyurea to selectively kill all cycling cells has been used to study population dynamics and life expectancy of “natural” immunoglobulin-secreting cells in the bone marrow and spleen of nonimmunized animals. The results show that 50 to 90% of those cells are eliminated 2 to 3 days after one cycle of hydroxyurea administration, demonstrating their recent origin from cycling precursors. Using a protocol of long-term hydroxyurea treatment which abrogates cell production from the cycling precursors compartments, it was shown that “natural” immunoglobulin-secreting cells have a very short half renewal time, in the range of 15-60 h.

http://www.ncbi.nlm.nih.gov/pubmed/3297735