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© Thomas Gregor
The image shows a Drosophila embryo 2 hr after fertilization, with nuclei at the surface fluorescently labeled for Bicoid protein (blue), Hunchback protein (green), and DNA (red). Using two-photon microscopy these embryos were imaged to quantitatively characterize the dynamics and precision of how morphogen molecules communicate positional information to individual nuclei. In this example, the shallow Bicoid gradient generates a sharp Hunchback boundary (enlarged in the background), partitioning the embryo in half. This input/output relationship is quantitatively represented in the foreground (yellow), where each dot specifies the Bicoid concentration (horizontal axis) and Hunchback concentration (vertical axis) measured in a single nucleus. The results indicate that the precision with which the embryo interprets and locates this boundary is very high, approaching limits set by simple physical principles.
Publication : Cold Spring Harbor perspectives in biology

The Impact of Space and Time on the Functional Output of the Genome.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cold Spring Harbor perspectives in biology - 06 Jul 2021

Nollmann M, Bennabi I, Götz M, Gregor T

Link to Pubmed [PMID] – 34230036

Link to DOI – a04037810.1101/cshperspect.a040378

Cold Spring Harb Perspect Biol 2021 Jul; ():

Over the past two decades, it has become clear that the multiscale spatial and temporal organization of the genome has important implications for nuclear function. This review centers on insights gained from recent advances in light microscopy on our understanding of transcription. We discuss spatial and temporal aspects that shape nuclear order and their consequences on regulatory components, focusing on genomic scales most relevant to function. The emerging picture is that spatiotemporal constraints increase the complexity in transcriptional regulation, highlighting new challenges, such as uncertainty about how information travels from molecular factors through the genome and space to generate a functional output.

https://pubmed.ncbi.nlm.nih.gov/34230036