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© Pierre Gounon
Entrée de Listeria dans une cellule épithéliale (Grossissement X 10000). Image colorisée.
Publication : Cellular and molecular life sciences : CMLS

The ever-growing complexity of the mitochondrial fission machinery

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cellular and molecular life sciences : CMLS - 05 Aug 2017

Pagliuso A, Cossart P, Stavru F

Link to Pubmed [PMID] – 28779209

Cell. Mol. Life Sci. 2018 Feb;75(3):355-374

The mitochondrial network constantly changes and remodels its shape to face the cellular energy demand. In human cells, mitochondrial fusion is regulated by the large, evolutionarily conserved GTPases Mfn1 and Mfn2, which are embedded in the mitochondrial outer membrane, and by OPA1, embedded in the mitochondrial inner membrane. In contrast, the soluble dynamin-related GTPase Drp1 is recruited from the cytosol to mitochondria and is key to mitochondrial fission. A number of new players have been recently involved in Drp1-dependent mitochondrial fission, ranging from large cellular structures such as the ER and the cytoskeleton to the surprising involvement of the endocytic dynamin 2 in the terminal abscission step. Here we review the recent findings that have expanded the mechanistic model for the mitochondrial fission process in human cells and highlight open questions.

https://www.ncbi.nlm.nih.gov/pubmed/28779209