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© Pierre Gounon
Entrée de Listeria dans une cellule épithéliale (Grossissement X 10000). Image colorisée.
Publication : Trends in cell biology

The Diverse Family of Arp2/3 Complexes

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in cell biology - 01 Feb 2017

Pizarro-Cerdá J, Chorev DS, Geiger B, Cossart P

Link to Pubmed [PMID] – 27595492

Trends Cell Biol. 2017 Feb;27(2):93-100

The Arp2/3 complex has so far been considered to be a single seven-subunit protein complex required for actin nucleation and actin filament polymerization in diverse critical cellular functions including phagocytosis, vesicular trafficking and lamellipodia extension. The Arp2/3 complex is also exploited by bacterial pathogens and viruses during cellular infectious processes. Recent studies suggest that some subunits of the complex are dispensable in specific cellular contexts, pointing to the existence of alternative ‘hybrid Arp2/3 complexes’ containing other components such as vinculin or α-actinin, as well as different isoforms or phosphorylation variants of canonical Arp2/3 subunits. Therefore, this diversity should be now considered when assigning specific Arp2/3 assemblies to different actin-dependent cellular processes.

https://www.ncbi.nlm.nih.gov/pubmed/27595492