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© Research
Publication : Médecine sciences : M/S

[The Collaborative Cross, a groundbreaking tool to tackle complex traits]

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Médecine sciences : M/S - 27 Jan 2012

Panthier JJ, Montagutelli X

Link to Pubmed [PMID] – 22289838

Med Sci (Paris) 2012 Jan;28(1):103-8

Complex traits, like the susceptibility to common diseases, are controlled by numerous genomic regions which individual effect is generally weak. These observations led geneticists to develop an experimental system to dissect the genetic of complex traits in the mouse. The Collaborative Cross (CC) is a genetic reference population of over 300 inbred lines derived from eight inbred strains of three Mus musculus sub-species that captures 90% of the genetic variation known in the mouse genome. We present here the generation and the characteristics of the CC and we report the results of the first experiments with partially inbred CC lines.

http://www.ncbi.nlm.nih.gov/pubmed/22289838