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© Amandine Buffet, Institut Pasteur
Snapshot of capsule staining of facultative pathogen Klebsiella pneumoniae
Publication : Antimicrobial agents and chemotherapy

The Capsule Increases Susceptibility to Last-Resort Polymyxins, but Not to Other Antibiotics, in Klebsiella pneumoniae.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antimicrobial agents and chemotherapy - 13 Mar 2023

D'Angelo F, Rocha EPC, Rendueles O,

Link to Pubmed [PMID] – 36912665

Link to DOI – 10.1128/aac.00127-23

Antimicrob Agents Chemother 2023 Mar; (): e0012723

The extracellular capsule is a virulence factor present in many facultative pathogens, but its role in antimicrobial resistance remains controversial. To shed light on this debate, we tested six antibiotics on four Klebsiella pneumoniae species complex strains. Noncapsulated strains exhibited increased tolerance to polymyxins, but not to other antibiotics, as measured using the MIC. Our results urge caution on the use of therapeutic agents that target the capsule and may result in selection for its inactivation.