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© Research
Publication : Nucleic acids research

Structural study of DNA duplex containing an N-(2-deoxy-beta-D-erythro-pentofuranosyl) formamide frameshift by NMR and restrained molecular dynamics

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nucleic acids research - 15 Oct 2003

Maufrais C, Fazakerley GV, Cadet J, Boulard Y

Link to Pubmed [PMID] – 14530441

Nucleic Acids Res. 2003 Oct;31(20):5930-40

The presence of an N-(2-deoxy-beta-D-erythro-pentofuranosyl) formamide (F) residue, a ring fragmentation product of thymine, in a frameshift context in the sequence 5′-d-(AGGACCACG)*d(CGTGGFTCCT) has been studied by 1H and 31P nuclear magnetic resonance (NMR) and molecular dynamics. Two-dimensional NMR studies show that the formamide residue, whether the cis or trans isomer, is rotated out of the helix and that the bases on either side of the formamide residue in the sequence, G14 and T16, are stacked over each other in a way similar to normal B-DNA. The cis and trans isomers were observed in the ratio 3:2 in solution. Information extracted from 31P NMR data reveal a modification of the phosphodiester backbone conformation at the extrahelical site, which is also observed during the molecular dynamics simulations.

https://www.ncbi.nlm.nih.gov/pubmed/14530441