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© Research
Publication : Drug discovery today

Stabilization of protein-protein interaction complexes through small molecules

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Drug discovery today - 03 Oct 2015

Zarzycka B, Kuenemann MA, Miteva MA, Nicolaes GA, Vriend G, Sperandio O

Link to Pubmed [PMID] – 26434617

Drug Discov. Today 2016 Jan;21(1):48-57

Most of the small molecules that have been identified thus far to modulate protein-protein interactions (PPIs) are inhibitors. Another promising way to interfere with PPI-associated biological processes is to promote PPI stabilization. Even though PPI stabilizers are still scarce, stabilization of PPIs by small molecules is gaining momentum and offers new pharmacological options. Therefore, we have performed a literature survey of PPI stabilization using small molecules. From this, we propose a classification of PPI stabilizers based on their binding mode and the architecture of the complex to facilitate the structure-based design of stabilizers.