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© Therese Couderc, Marc Lecuit
Publication : Developmental cell

SAS-6 assembly templated by the lumen of cartwheel-less centrioles precedes centriole duplication

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Developmental cell - 10 Jul 2014

Fong CS, Kim M, Yang TT, Liao JC, Tsou MF

Link to Pubmed [PMID] – 25017693

Dev. Cell 2014 Jul;30(2):238-45

Centrioles are 9-fold symmetric structures duplicating once per cell cycle. Duplication involves self-oligomerization of the centriolar protein SAS-6, but how the 9-fold symmetry is invariantly established remains unclear. Here, we found that SAS-6 assembly can be shaped by preexisting (or mother) centrioles. During S phase, SAS-6 molecules are first recruited to the proximal lumen of the mother centriole, adopting a cartwheel-like organization through interactions with the luminal wall, rather than via their self-oligomerization activity. The removal or release of luminal SAS-6 requires Plk4 and the cartwheel protein STIL. Abolishing either the recruitment or the removal of luminal SAS-6 hinders SAS-6 (or centriole) assembly at the outside wall of mother centrioles. After duplication, the lumen of engaged mother centrioles becomes inaccessible to SAS-6, correlating with a block for reduplication. These results lead to a proposed model that centrioles may duplicate via a template-based process to preserve their geometry and copy number.

https://www.ncbi.nlm.nih.gov/pubmed/25017693