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© Pierre Gounon
Entrée de Listeria dans une cellule épithéliale (Grossissement X 10000). Image colorisée.
Publication : Trends in microbiology

RNA-mediated control of virulence gene expression in bacterial pathogens

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in microbiology - 01 Jun 2003

Johansson J, Cossart P

Link to Pubmed [PMID] – 12823945

Trends Microbiol. 2003 Jun;11(6):280-5

Until recently, gene expression was thought to be controlled mainly at the level of transcription initiation by repressor or activator proteins. In some cases, transcription elongation is controlled by a so-called attenuation mechanism that involves alternative base-pairing between different regions of an mRNA transcript. Recent data reveal that other mechanisms can regulate gene expression and involve RNAs that might act as antisense RNAs, sequestering molecules, or thermosensors. This review focuses on recent studies in bacterial pathogens in which a growing list of examples show that RNA can control virulence gene expression.

http://www.ncbi.nlm.nih.gov/pubmed/12823945