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© William Beaucardet
Reportage Unité Intéractions bactéries cellules
Publication : Journal of the American Academy of Dermatology

Rifampin-moxifloxacin-metronidazole combination therapy for severe Hurley Stage 1 Hidradenitis Suppurativa: prospective short-term trial and one-year follow-up in 28 consecutive patients.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of the American Academy of Dermatology - 10 Jan 2020

Delage M, Jais JP, Lam T, Guet-Revillet H, Ungeheuer MN, Consigny PH, Nassif A, Join-Lambert O,

Link to Pubmed [PMID] – 31931082

Link to DOI – S0190-9622(20)30049-910.1016/j.jaad.2020.01.007

J Am Acad Dermatol 2020 Jan; ():

Severe Hurley stage 1 Hidradenitis suppurativa (HS1) is a difficult to treat form of the disease.To assess the efficacy and tolerance of the oral combination of rifampin (10 mg/kg once daily) – moxifloxacin (400 mg once daily) – metronidazole (250 to 500 mg t.i.d) (RMoM) treatment strategy in severe HS1 patients.Prospective, open-label, non-comparative cohort study in 28 consecutive patients. 19 patients were treated for 6 weeks by RMoM, followed by 4 weeks of RMo alone, then by cotrimoxazole after remission. Moxifloxacin was replaced by pristinamycin (1g t.i.d) in 9 cases because of contra-indications or intolerance. Primary endpoint was a Sartorius score of 0 (clinical remission, CR) at week 12.The median Sartorius score dropped from 14 to 0 (p= 6 x 10-6) at week 12, 75% of patients reaching CR. A low initial Sartorius score was a prognosis factor for CR (p = 0.049). Main side-effects were mild gastro-intestinal discomfort, mucosal candidiasis and asthenia. At one year of follow-up, the median [IQR] number of flares dropped from 21/year to 1 (p = 10-5).small monocentric non-controlled study.complete and prolonged remission can be obtained in severe HS1 using targeted antimicrobial treatments.

https://pubmed.ncbi.nlm.nih.gov/31931082