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© Uwe Maskos
Tranche d'hippocampe de souris colorée avec deux toxines spécifiques de sous-types de récepteur nicotinique, en rouge (grains), et en vert (corps cellulaires). L'hippocampe est la zone du cerveau qui gère la mémoire spatiale.
Publication : Psychiatry research

Relevance of treated cocaine users’ retrospective memory of first cocaine use.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Psychiatry research - 01 Jun 2018

Karsinti E, Piani K, Zerdazi EH, Maskos U, Faure P, Romo L, Bellivier F, Brousse G, Lépine JP, Bloch V, Vorspan F,

Link to Pubmed [PMID] – 29653350

Link to DOI [DOI] – S0165-1781(17)30725-410.1016/j.psychres.2018.03.058

Psychiatry Res 2018 06; 264(): 210-216

Little is known regarding between-subject variability in the subjective effects of first cocaine use. This study retrospectively assesses the subjective effects of first cocaine use in 160 current treatment-seeking cocaine use disorder patients. Subjective effects of first cocaine use were evaluated with an ad-hoc questionnaire used for cannabis effects. A principal component analysis (PCA) was performed, with resulting factors correlated with clinical variables (α = 0.05). Four factors emerged in the PCA, namely Anxiety (accounting for 21.5% of questionnaire variance), Disinhibition (17.3%), Tachypsychia (16%) and Calmness (13%). Male gender was associated with Disinhibition and Tachypsychia. Cocaine severity factors were associated with Disinhibition, Tachypsychia and Calmness. Opiate, sedative and poppers uses were associated with Anxiety, Tachypsychia and Calmness. The retrospective assessment of the subjective effects of first cocaine use shows significant variability. The different dimensions of subjective first effects are influenced by age, gender and previous substance use history, as well as characteristics of first cocaine use and cocaine-related outcomes.

https://pubmed.ncbi.nlm.nih.gov/29653350