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© Research
Publication : Physical review. E, Statistical, nonlinear, and soft matter physics

Quantitative analysis of virus and plasmid trafficking in cells

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Physical review. E, Statistical, nonlinear, and soft matter physics - 28 Jan 2009

Lagache T, Dauty E, Holcman D

Link to Pubmed [PMID] – 19257083

Phys Rev E Stat Nonlin Soft Matter Phys 2009 Jan;79(1 Pt 1):011921

Intracellular transport of DNA carriers is a fundamental step of gene delivery. By combining both theoretical and numerical approaches we study here single and several viruses and DNA particles trafficking in the cell cytoplasm to a small nuclear pore. We present a physical model to account for certain aspects of cellular organization, starting with the observation that a viral trajectory consists of epochs of pure diffusion and epochs of active transport along microtubules. We define a general degradation rate to describe the limitations of the delivery of plasmid or viral particles to a nuclear pore imposed by various types of direct and indirect hydrolysis activity inside the cytoplasm. By replacing the switching dynamics by a single steady state stochastic description, we obtain estimates for the probability and the mean time for the first one of many particles to go from the cell membrane to a small nuclear pore. Computational simulations confirm that our model can be used to analyze and interpret viral trajectories and estimate quantitatively the success of nuclear delivery.

https://www.ncbi.nlm.nih.gov/pubmed/19257083