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© Research
Publication : Antimicrobial agents and chemotherapy

Protein O-mannosyltransferase isoforms regulate biofilm formation in Candida albicans

Team: Fungal Biology and Pathogenicity
Member: Christophe D’Enfert
Member: Sophie Goyard
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antimicrobial agents and chemotherapy - 01 Oct 2006

Peltroche-Llacsahuanga H, Goyard S, d'Enfert C, Prill SK, Ernst JF

Link to Pubmed [PMID] – 17005840

Antimicrob. Agents Chemother. 2006 Oct;50(10):3488-91

Five isoforms of protein mannosyltransferase (Pmt) O-mannosylate secretory proteins in Candida albicans. pmt mutants were differentially defective for biofilm formation on plastic in static and flow-through systems, and a Pmt inhibitor blocked early stages of biofilm formation. Conceptually, Pmt inhibition may prevent surface anchoring and biofilm-dependent resistance of fungal pathogens.