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© Pierre Gounon
Entrée de Listeria dans une cellule épithéliale (Grossissement X 10000). Image colorisée.
Publication : Nature reviews. Genetics

Prokaryotic transcriptomics: a new view on regulation, physiology and pathogenicity

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature reviews. Genetics - 24 Nov 2009

Sorek R, Cossart P

Link to Pubmed [PMID] – 19935729

Nat. Rev. Genet. 2010 Jan;11(1):9-16

Transcriptome-wide studies in eukaryotes have been instrumental in the characterization of fundamental regulatory mechanisms for more than a decade. By contrast, in prokaryotes (bacteria and archaea) whole-transcriptome studies have not been performed until recently owing to the general view that microbial gene structures are simple, as well as technical difficulties in enriching for mRNAs that lack poly(A) tails. Deep RNA sequencing and tiling array studies are now revolutionizing our understanding of the complexity, plasticity and regulation of microbial transcriptomes.

http://www.ncbi.nlm.nih.gov/pubmed/19935729