Link to Pubmed [PMID] – 19243939
Bioorg. Med. Chem. Lett. 2009 Mar;19(6):1715-7
A quinazoline that decreases polyglutamine aggregate burden in a cell-based assay was identified from a high-throughput screen of a chemical-compound library, provided by the NIH Molecular Libraries Small Molecule Repository (MLSMR). A structure and activity study yielded leads with submicromolar potency.