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© Research
Publication : Bioorganic & medicinal chemistry letters

Potent inhibitors of Huntingtin protein aggregation in a cell-based assay

Team: Photonic BioImaging (UTechS PBI)
Member: Nathalie Aulner
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Bioorganic & medicinal chemistry letters - 30 Jan 2009

Rinderspacher A, Cremona ML, Liu Y, Deng SX, Xie Y, Gong G, Aulner N, Többen U, Myers K, Chung C, Andersen M, Vidović D, Schürer S, Brandén L, Yamamoto A, Landry DW

Link to Pubmed [PMID] – 19243939

Bioorg. Med. Chem. Lett. 2009 Mar;19(6):1715-7

A quinazoline that decreases polyglutamine aggregate burden in a cell-based assay was identified from a high-throughput screen of a chemical-compound library, provided by the NIH Molecular Libraries Small Molecule Repository (MLSMR). A structure and activity study yielded leads with submicromolar potency.