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© Research
Publication : Malaria journal

Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in Cambodia

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Malaria journal - 12 Jan 2009

Lim P, Alker AP, Khim N, Shah NK, Incardona S, Doung S, Yi P, Bouth DM, Bouchier C, Puijalon OM, Meshnick SR, Wongsrichanalai C, Fandeur T, Le Bras J, Ringwald P, Ariey F

Link to Pubmed [PMID] – 19138391

Malar. J. 2009;8:11

The combination of artesunate and mefloquine was introduced as the national first-line treatment for Plasmodium falciparum malaria in Cambodia in 2000. However, recent clinical trials performed at the Thai-Cambodian border have pointed to the declining efficacy of both artesunate-mefloquine and artemether-lumefantrine. Since pfmdr1 modulates susceptibility to mefloquine and artemisinin derivatives, the aim of this study was to assess the link between pfmdr1 copy number, in vitro susceptibility to individual drugs and treatment failure to combination therapy.

http://www.ncbi.nlm.nih.gov/pubmed/19138391