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© Research
Publication : Nature medicine

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer’s disease.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature medicine - 01 Feb 2016

Baruch K, Deczkowska A, Rosenzweig N, Tsitsou-Kampeli A, Sharif AM, Matcovitch-Natan O, Kertser A, David E, Amit I, Schwartz M,

Link to Pubmed [PMID] – 26779813

Link to DOI – 10.1038/nm.4022

Nat Med 2016 Feb; 22(2): 135-7

Systemic immune suppression may curtail the ability to mount the protective, cell-mediated immune responses that are needed for brain repair. By using mouse models of Alzheimer’s disease (AD), we show that immune checkpoint blockade directed against the programmed death-1 (PD-1) pathway evokes an interferon (IFN)-γ-dependent systemic immune response, which is followed by the recruitment of monocyte-derived macrophages to the brain. When induced in mice with established pathology, this immunological response leads to clearance of cerebral amyloid-β (Aβ) plaques and improved cognitive performance. Repeated treatment sessions were required to maintain a long-lasting beneficial effect on disease pathology. These findings suggest that immune checkpoints may be targeted therapeutically in AD.