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© Pierre Gounon
Entrée de Listeria dans une cellule épithéliale (Grossissement X 10000). Image colorisée.
Publication : Cell

Pathogen-mediated posttranslational modifications: A re-emerging field

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cell - 24 Nov 2010

Ribet D, Cossart P

Link to Pubmed [PMID] – 21111231

Cell 2010 Nov;143(5):694-702

Posttranslational modifications are increasingly recognized as key strategies used by bacterial and viral pathogens to modulate host factors critical for infection. A number of recent studies illustrate how pathogens use these posttranslational modifications to target central signaling pathways in the host cell, such as the NF-kB and MAP kinase pathways, which are essential for pathogens’ replication, propagation, and evasion from host immune responses. These discoveries open new avenues for investigating the fundamental mechanisms of pathogen infection and the development of new therapeutics.

http://www.ncbi.nlm.nih.gov/pubmed/21111231