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© Research
Publication : Molecular microbiology

Overexpression approaches to advance understanding of Candida albicans.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Molecular microbiology - 27 Sep 2021

Rai LS, van Wijlick L, Chauvel M, d'Enfert C, Legrand M, Bachellier-Bassi S,

Link to Pubmed [PMID] – 34569668

Link to DOI – 10.1111/mmi.14818

Mol Microbiol 2021 Sep; ():

Candida albicans is an opportunistic fungal pathogen that is responsible for infections linked to high mortality. Loss-of-function approaches, taking advantage of gene knockouts or inducible down-regulation, have been successfully used in this species in order to understand gene function. However, overexpression of a gene provides an alternative, powerful tool to elucidate gene function and identify novel phenotypes. Notably, overexpression can identify pathway components that might remain undetected using loss-of-function approaches. Several repressible or inducible promoters have been developed which allow to shut off or turn on the expression of a gene in C. albicans upon growth in the presence of a repressor or inducer. In this review, we summarize recent overexpression approaches used to study different aspects of C. albicans biology, including morphogenesis, biofilm formation, drug tolerance and commensalism.

https://pubmed.ncbi.nlm.nih.gov/34569668