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© Research
Publication : Methods in molecular biology (Clifton, N.J.)

Optimized Protein-Protein Interaction Network Usage with Context Filtering

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Methods in molecular biology (Clifton, N.J.) - 01 Jan 2018

Pietrosemoli N, Dobay MP

Link to Pubmed [PMID] – 30421398

Methods Mol. Biol. 2018;1819:33-50

Protein-protein interaction networks (PPIs) collect information on physical-and in some cases-functional interactions between proteins. Most PPIs are annotated with confidence scores, which reflect the probability that a reported interaction is a true interaction. These scores, however, do not allow users to isolate interactions relevant in a particular biological context. Here, we describe solutions for performing context filtering on PPIs to allow biological data interpretation and functional inference in two publicly available PPIs resources (HIPPIE and STRING) and in the proprietary pathway analysis tool and knowledge base Ingenuity Pathway Analysis.

https://www.ncbi.nlm.nih.gov/pubmed/30421398