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© Perthame&Millot
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Publication : The Journal of infection

Optimal combination of early biomarkers for infection and sepsis diagnosis in the emergency department: The BIPS study.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of infection - 18 Feb 2021

Velly L, Volant S, Fitting C, Ghazali DA, Salipante F, Mayaux J, Monsel G, Cavaillon JM, Hausfater P,

Link to Pubmed [PMID] – 33610685

Link to DOI – S0163-4453(21)00089-X10.1016/j.jinf.2021.02.019

J Infect 2021 Feb; ():

To define the best combination of biomarkers for the diagnosis of infection and sepsis in the emergency room.In this prospective study, consecutive patients with a suspicion of infection in the emergency room were included. Eighteen different biomarkers measured in plasma, and twelve biomarkers measured on monocytes, neutrophils, B and T-lymphocytes were studied and the best combinations determined by a gradient tree boosting approach.Overall, 291 patients were included and analysed, 148 with bacterial infection, and 47 with viral infection. The best biomarker combination which first allowed the diagnosis of bacterial infection, included HLA-DR (human leukocyte antigen DR) on monocytes, MerTk (Myeloid-epithelial-reproductive tyrosine kinase) on neutrophils and plasma metaloproteinase-8 (MMP8) with an area under the curve (AUC) = 0.94 [95% confidence interval (IC95): 0.91;0.97]. Among patients in whom a bacterial infection was excluded, the combination of CD64 expression, and CD24 on neutrophils and CX3CR1 on monocytes ended to an AUC = 0.98 [0.96;1] to define those with a viral infection.In a convenient cohort of patients admitted with a suspicion of infection, two different combinations of plasma and cell surface biomarkers were performant to identify bacterial and viral infection.

https://pubmed.ncbi.nlm.nih.gov/33610685