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  • PhD Student
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  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
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© Research
Publication : Biochimie

Nucleic acid aptamers for neurodegenerative diseases.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Biochimie - 01 Feb 2018

Bouvier-Müller A, Ducongé F,

Link to Pubmed [PMID] – 29104136

Link to DOI – 10.1016/j.biochi.2017.10.026S0300-9084(17)30279-1

Biochimie 2018 Feb; 145(): 73-83

The increased incidence of neurodegenerative diseases represents a huge challenge for societies. These diseases are characterized by neuronal death and include several different pathologies, such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, Huntington’s disease and transmissible spongiform encephalopathies. Most of these pathologies are often associated with the aggregation of misfolded proteins, such as amyloid-ß, tau, α-synuclein, huntingtin and prion proteins. However, the precise mechanisms that lead to neuronal dysfunction and death in these diseases remain poorly understood. Nucleic acid aptamers represent a new class of ligands that could be useful to better understand these diseases and develop better diagnosis and therapy. In this review, several of these aptamers are presented as well as their applications for neurodegenerative diseases.