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© Institut Pasteur
Macrophages et lymphocytes de souris. Image colorisée.
Publication : Nature immunology

Notch signaling is necessary for adult, but not fetal, development of RORγt(+) innate lymphoid cells

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature immunology - 11 Sep 2011

Possot C, Schmutz S, Chea S, Boucontet L, Louise A, Cumano A, Golub R

Link to Pubmed [PMID] – 21909092

Nat. Immunol. 2011 Oct;12(10):949-58

The transcription factor RORγt is required for the development of several innate lymphoid populations, such as lymphoid tissue-inducer cells (LTi cells) and cells that secrete interleukin 17 (IL-17) or IL-22. The progenitor cells as well as the developmental stages that lead to the emergence of RORγt(+) innate lymphoid cells (ILCs) remain undefined. Here we identify the chemokine receptor CXCR6 as an additional marker of the development of ILCs and show that common lymphoid progenitors lost B cell and T cell potential as they successively acquired expression of the integrin α(4)β(7) and CXCR6. Whereas fetal RORγt(+) cells matured in the fetal liver environment, adult bone marrow-derived RORγt(+) ILCs matured outside the bone marrow, in a Notch2-dependent manner. Therefore, fetal and adult environments influence the differentiation of RORγt(+) cells differently.

http://www.ncbi.nlm.nih.gov/pubmed/21909092