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© Research
Publication : Frontiers in microbiology

Clinical Impact of Antifungal Susceptibility, Biofilm Formation and Mannoside Expression of Yeasts on the Outcome of Invasive Candidiasis in ICU: An Ancillary Study on the Prospective AmarCAND2 Cohort

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Frontiers in microbiology - 11 Dec 2018

Gangneux JP, Cornet M, Bailly S, Fradin C, Féger C, Timsit JF, Leroy O, Sendid B, Bougnoux ME

Link to Pubmed [PMID] – 30619103

Front Microbiol 2018;9:2907

The link between phenotypical characteristics and invasive candidiasis (IC) prognosis is still partially unknown. strains isolated during the AmarCAND2 study were centrally analyzed for species identification, antifungal susceptibility, biofilm formation, and expression of surface and glycoconjugate mannosides. Correlation between these phenotypical features and patient outcome was sought using a multivariable Cox survival model. was predominant (65.4%, = 285), with a mortality rate significantly lower than that in patients with non- strains [HR 0.67 (0.46-1.00), = 0.048]. The rate of fluconazole-resistant strains was low ( and : 3.5 and 6.2%, respectively) as well as caspofungin-resistant ones (1 and 3.1%, respectively). Early biofilm formation was less frequent among (45.4%) than among non- (81.2%). While the strains of showed variable levels of surface mannosides expression, strains isolated from candidemia exhibited a high expression of β-man, which was correlated with an increased mortality ( = 0.02). IC were associated with lower mortality, and with strains that exhibited less frequently early biofilm formation than non- strains. A high expression of β-man was associated with increased IC mortality. Further studies are warranted to confirm this data and to evaluate other virulence factors in yeasts.

https://www.ncbi.nlm.nih.gov/pubmed/30619103