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© Xavier Montagutelli, Institut Pasteur
Publication : PloS one

Nasal bone shape is under complex epistatic genetic control in mouse interspecific recombinant congenic strains

Team: Mouse Genetics
Member: Xavier Montagutelli
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PloS one - 25 May 2012

Burgio G, Baylac M, Heyer E, Montagutelli X

Link to Pubmed [PMID] – 22662199

PLoS ONE 2012;7(5):e37721

Genetic determinism of cranial morphology in the mouse is still largely unknown, despite the localization of putative QTLs and the identification of genes associated with Mendelian skull malformations. To approach the dissection of this multigenic control, we have used a set of interspecific recombinant congenic strains (IRCS) produced between C57BL/6 and mice of the distant species Mus spretus (SEG/Pas). Each strain has inherited 1.3% of its genome from SEG/Pas under the form of few, small-sized, chromosomal segments.