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© Research
Publication : Nature communications

NACA deficiency reveals the crucial role of somite-derived stromal cells in haematopoietic niche formation

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature communications - 28 Sep 2015

Murayama E, Sarris M, Redd M, Le Guyader D, Vivier C, Horsley W, Trede N, Herbomel P

Link to Pubmed [PMID] – 26411530

Nat Commun 2015;6:8375

The ontogeny of haematopoietic niches in vertebrates is essentially unknown. Here we show that the stromal cells of the caudal haematopoietic tissue (CHT), the first niche where definitive haematopoietic stem/progenitor cells (HSPCs) home in zebrafish development, derive from the caudal somites through an epithelial-mesenchymal transition (EMT). The resulting stromal cell progenitors accompany the formation of the caudal vein sinusoids, the other main component of the CHT niche, and mature into reticular cells lining and interconnecting sinusoids. We characterize a zebrafish mutant defective in definitive haematopoiesis due to a deficiency in the nascent polypeptide-associated complex alpha subunit (NACA). We demonstrate that the defect resides not in HSPCs but in the CHT niche. NACA-deficient stromal cell progenitors initially develop normally together with the sinusoids, and HSPCs home to the resulting niche, but stromal cell maturation is compromised, leading to a niche that is unable to support HSPC maintenance, expansion and differentiation.

http://www.ncbi.nlm.nih.gov/pubmed/26411530