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© Research
Publication : Proceedings of the National Academy of Sciences of the United States of America

Mouse kidney and submaxillary gland renin genes differ in their 5′ putative regulatory sequences

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Proceedings of the National Academy of Sciences of the United States of America - 01 Sep 1984

Panthier JJ, Dreyfus M, Roux TL, Rougeon F

Link to Pubmed [PMID] – 6089205

Proc. Natl. Acad. Sci. U.S.A. 1984 Sep;81(17):5489-93

The genomic DNAs that specify the renin mRNAs found in the submaxillary gland and in the kidney of Swiss mice have been isolated by molecular cloning in phage lambda. The Ren1 and Ren2 genes, encoding the kidney and submaxillary renins, respectively, span about 9.5 kilobases each. Restriction maps of both renin genes and their flanking sequences are presented. To correlate the differential expression of the renin genes with their structures, a sequence analysis of the putative 5′ regulatory sequences of both genes was conducted. The results show that the leader sequences and promoter regions of both genes are highly homologous to a point located 179 nucleotides upstream from the transcription start point; the sequences diverge beyond this position.

http://www.ncbi.nlm.nih.gov/pubmed/6089205