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© Research
Publication : Nature structural & molecular biology

Molecular profiling of common fragile sites in human fibroblasts

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature structural & molecular biology - 06 Nov 2011

Le Tallec B, Dutrillaux B, Lachages AM, Millot GA, Brison O, Debatisse M

Link to Pubmed [PMID] – 22056772

Nat. Struct. Mol. Biol. 2011 Nov;18(12):1421-3

Common fragile sites have been mapped primarily in lymphocytes, but recent analyses show that the setting of these sites relies on cell type-dependent replication programs. Using a new approach, we molecularly mapped common fragile sites in human fibroblasts and showed that commitment to fragility depends on similar replication features in fibroblasts and lymphocytes, although different loci are committed in each cell type. Notably, the common fragile sites that we identified overlapped heretofore unexplained deletion clusters observed in tumors.

https://www.ncbi.nlm.nih.gov/pubmed/22056772